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187 Additionally, H3K18la impedes retinoic acid receptor gamma (RAR) expression, which interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6) and subsequently inhibits NF-B-mediated inflammatory signaling within the TME

on the other hand, it functions as an autonomous entity and a driver of transformative action (Zimmermann, 2023)

Tocotrienols have demonstrated inhibitory effects on the phosphorylation of the PI3k/Akt signaling pathway, resulting in the downregulation of key signaling molecules including endothelial nitric oxide synthase (eNOS), glycogen synthase kinase 3 (GSK3), and extracellular signal-regulated kinase (ERK)