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For signals to be sent from neuron to neuron, not only does the neurotransmitter have to be released into the synapse, but it also has to be received in a receptor, which then sets off a chain of events to send on the signal

Hunter CJ, Matyas JR, Duncan NA: The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering

These observations further suggests that the hypoxic microenvironment is closely associated with the development of cutaneous calciphylaxis in MS patients and is involved in their vascular pathology and calcium salt deposition

Some patients may notice symptoms returning before their next scheduled injection, particularly if they have higher metabolic demands or ongoing neurological involvement