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Therefore, CB-27 and CB-59 were predicted to have high Caco2 permeability

At the gastric level, cagrilintide significantly slows gastric emptying and food transit through the gastrointestinal tract

Particularly, genes involved in lipid metabolism ( Abcg5 ), drug metabolism ( Cyp2a4 ), GSH metabolism ( Gstm2 and Gstm6 ), and oxidative phosphorylation ( Lhpp ) were expressed at higher levels in the liver of hepsin / mice compared with wild-type mice