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indicates that PAC, in the absence of adequate, physiological levels of GSH, may give rise to genotoxic quinone imine metabolites ( The production of quinone imine metabolite is the primary responsible for PAC liver and kidney toxicity

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Specific to brain disorders, NAC has been trialed with some efficacy in patients with Alzheimers disease 50 , and our data suggest that it warrants further investigation for effectiveness in HCCAA