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Gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), tryptophan metabolites, and immune stimulants, are likely mediators in this process [85]

The peptide exhibits high-affinity copper binding (Kd ~10 M), creating a stable complex that delivers copper to cells while protecting against copper-induced oxidative damage

[8] In other words, TB-500 is usually a short fragment built around T4s active site not the full-length protein that appears in the human clinical literature