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77 In poorly controlled RA patients, bony erosions become evident on radiographs within 2 years of onset and these erosive changes are predictive of poorer functional outcome

doi: 10.1038/nrc2397 25 TilkiDKilicNSevincSZywietzFStiefCGErgunS

Indeed, the liver has been reported to need a maximal synthesis of GSH for detoxifying exogenous xenobiotics, such as acetaminophen 75,76

Mechanistic studies demonstrated that xanthohumol suppresses IL-1 expression, enhances IL-10 production, and mitigates CuSO 4 -induced oxidative stress