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Enzymatic Cofactor Activity : Serves as an essential cofactor for glutathione peroxidase and glutathione reductase enzymes, enabling these protective systems to neutralize hydrogen peroxide and lipid peroxides that would otherwise damage cellular membranes

Longer half-life compounds would increase the risk of off-target effects and dose accumulation over multi-day protocols, while dihexas rapid clearance enables daily dosing with predictable kinetics and minimal carryover between doses

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DECLARATIONS Authors contributions Drafted the manuscript: Valds-Calero I Revised the manuscript critically for important intellectual content: Rodrguez A, Frhbeck G All authors participated in final approval of the version to be published