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In inflammation, IL-10 can reduce the antigen-presenting function by downregulating the expression of Mononuclear Cell Surface II major histocompatibility antigens (Class II major histocompatibility complex, MHC II), and inhibit inflammatory cell activation, migration, and adhesion by downregulating the activity of T cells
The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed
Also, it protects them from environmental stresses like pollution, sunlight, as well as toxins
I modelli sperimentali hanno mostrato unaccelerata organizzazione delle fibre di collagene, lattivazione dei fibroblasti e una migliore resistenza alla trazione dopo le lesioni
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