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10.1016/j.neuroscience.2018.06.046 27

doi: 10.1038/s41598-019-44147-w 130

600mg N-Acetyl-L-Cysteine (NAC) per daily serving a stable, bioavailable cysteine precursor in the glutathione synthesis pathway

Abbreviations AKT: Protein kinase B AMH: Anti-Mllerian hormone AMPK/mTOR: AMP-activated protein kinase/mechanistic target of rapamycin ARE: Antioxidant response element AS-IV: Astragaloside IV ATP: Adenosine triphosphate BP: Biological process CC: Cellular component CCK8: Cell Counting Kit-8 C646: EP300 histone acetyltransferase inhibitor C646 CPT1A: Carnitine palmitoyltransferase 1A CTSB: Cathepsin B DEGs: Differentially expressed genes ECM: Extracellular matrix ELISA: Enzyme-linked immunosorbent assay E2 (estradiol): Estradiol EP300: E1A binding protein p300 FSH: Follicle-stimulating hormone GEO: Gene Expression Omnibus GLP-1: Glucagon-like peptide-1 GO: Gene Ontology GPx: Glutathione peroxidase H&E: Hematoxylin and eosin HMOX1: Heme oxygenase 1 IL-1: Interleukin-1 beta IL-6: Interleukin-6 IR: Insulin resistance KEAP1: Kelch-like ECH-associated protein 1 KEGG: Kyoto Encyclopedia of Genes and Genomes KGN: Human ovarian granulosa-like tumor cell line LH: Luteinizing hormone MAPK: Mitogen-activated protein kinase ML385: Nrf2 inhibitor ML385 MMP9: Matrix metallopeptidase 9 MF: Molecular function NFE2L2: Nuclear factor erythroid 2related factor 2 NLRP3: NLR family pyrin domain containing 3 NRF1: Nuclear respiratory factor 1 PBS: Phosphate-buffered saline PCOS: Polycystic ovary syndrome PI3K: Phosphoinositide 3-kinase PPAR signaling pathway: Peroxisome proliferator-activated receptor gamma signaling pathway P450: Cytochrome P450 PTGS2: Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2, COX-2) PPI: Proteinprotein interaction PYGL: Glycogen phosphorylase, liver form qPCR: Quantitative polymerase chain reaction RCTs: Randomized controlled trials RelA/p65: NF-B subunit RelA/p65 SOD1: Superoxide dismutase 1 TIMP1: Tissue inhibitor of metalloproteinases 1 TLR4/MyD88/NF-B: Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B TNF-: Tumor necrosis factor alpha TFAM: Mitochondrial transcription factor A T (testosterone): Testosterone VEGFA: Vascular endothelial growth factor A WGCNA: Weighted Gene Co-Expression Network Analysis References Abuelezz NZ, Shabana ME, Abdel-Mageed HM et al (2020) Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: insights on PI3K/AkT/mTOR and TNF- modulations