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The primary outcome measure was safety, and key secondary outcomes were mean change from baseline best- corrected visual acuity (BCVA), mean change from baseline macular sensitivity measured by microperimetry, change from baseline in ellipsoid zone width at weeks 12 and 24, and NAC levels in the aqueous humor and in plasma

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Furthermore, LPS stimulation suppresses the expression of zinc importers (Zip6 and Zip10) while upregulating zinc exporters (ZnT1, ZnT4 and ZnT6), resulting in a net reduction of intracellular zinc

[141] There were concerns expressed that the amount of folate added was insufficient