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The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice ( c plus cytochrome c oxidase system ( Although the dismutation of superoxide by SOD2 is a predominant source of H 2 O 2 , there are other reactions that directly generate H 2 O 2 in mitochondria

Once delivered, these precursors increase levels of in the brain, which is essential for: Mitochondrial ATP Production: Fueling the high-energy demands of neurons

Chemokines (CCchemokine ligand 2 (CCL2) and CXCchemokine ligand 10 (CXCL10)) and pro-inflammatory mediators (TNF and IL-6) secreted either from the activated endothelium (10) or from surrounding immune cells further increase leukocyte adhesion and promote crawling over the luminal endothelial surface (9)