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Certain gut-derived peptides (such as GLP1 analogs) indirectly elevate testosterone by reducing body fat, improving insulin sensitivity and lowering aromatase activity, which preserves testosterone

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A 49 is an example of one such high affinity copper binding agent that is a main product of the further cleavage of A 1-40 by neprilysin (Stefaniak et al., 2021)

BPC-157, by activating eNOS and upregulating VEGF simultaneously, may be engaging both arms of this autocrine loop