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Medical management included Maalox 30 mL, famotidine 20 mg, ondansetron 4 mg, metoclopramide 10 mg, IV acetaminophen 1 g, and IV morphine 4 mg

doi: 10.2298/APT1546091S 230 LiuQZhangMBhandariBXuJYangC

Senolytics improve physical function and increase lifespan in old age

Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)