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Appetite, pp 171179

They carry chemical modifications that enhance the affinity for the target miRNA and trap the endogenous miRNA in a configuration that is unable to be processed by RNA-induced silencing complex (RISC), or alternatively, lead to the degradation of the endogenous miRNA

An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)