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69 El MammeriN.HierrezueloJ.TolchardJ.Cmara-AlmirnJ.Caro-AstorgaJ.lvarez-MenaA.et al (2019)

Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells

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Discontinue GTE if ALT or AST exceeds 1.5 times the upper limit of normal (a more conservative threshold than the iPLEDGE hold criteria, given the additive exposure)