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The use of anti-infective agents or pyrimethamine may invalidate diagnostic assays for folic acid and vitamin B12
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Further work is required to understand additional EV-derived signals that are released by adipose tissue in response to lipolysis and the mechanisms of release
The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)
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