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The glucagon receptor in retatrutide promotes fat oxidation specifically, which theoretically shifts the fat-to-lean-mass loss ratio more favorably

HSS Journal (2025) 8

A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR