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Glutamine is critical for (i) NK cells [191] and Teffs responses, especially Th17 cells and CD8 + T cells, while its absence is associated with Treg cells development in vitro, under Th1-inducing conditions [192,193,194]

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The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)