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Since there is a correlation between cancer development and fungal pathogenesis, antifungal drugs can be repurposed to downregulate oncogenes, which will eventually lead to tumor cell apoptosis

Additionally, all three compounds increased antioxidant enzyme activity (SOD, APX and CAT), with melatonin showing the highest increases (25 %, 42.86 % and 31.5 %)

Furthermore, glutathione is strictly required for the biochemical synthesis of DNA building blocks

p-eIF4E staining was done using mouse anti-elF4E (pS209) (BD 560229) diluted 1:100 and cells were fixed with BD Cytofix/Perm and intracellular staining was done in BD Perm (BD 554714)